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[13] A cardiovascular-outcomes trial of this size matters especially for a glucagon-containing molecule, because the glucagon axiss effects on heart rate and glucose make long-term cardiovascular safety a first-order question rather than an afterthought

Cell Mol Biol Lett 14: 2334, 2009 [DOI] [PMC free article] [PubMed] [Google Scholar] 77.Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, and Woodman RC

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However, its important to keep one foot on the ground: while results have been encouraging, scientists and dermatologists agree that larger, longer-term studies are still needed to truly understand the long-term safety and effectiveness of peptide therapy