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Acknowledgements The computations in this paper were performed on the ASTRA High Performance Computing Cluster supported by National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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A community-driven global reconstruction of human metabolism

Our findings add to the growing body of research on the role of the brainstem in opioid-induced constipation by revealing a PVN Glu DMV Ach circuit that directly modulates small intestinal function in response to morphine