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This article reviews the latest research results and mechanisms of crosstalk between mitochondrial quality control and metal-dependent cell death in recent years, as well as their involvement in neurodegenerative diseases, tumors and other diseases, in order to provide new ideas for the research and treatment of related diseases

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Heartburn or acid reflux Chest pain or discomfort Difficulty swallowing Regurgitation of food or liquids Shortness of breath Bloating or burping after meals Several factors may contribute to the development: Age-related weakening of the diaphragm Chronic coughing or straining during bowel movements Injury or trauma to the abdominal area Increased pressure in the abdomen (due to obesity, pregnancy, or heavy lifting) Sliding Hiatal Hernia Most common type, where the stomach and esophagus slide in and out of the chest through the hiatus

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