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It is worth dwelling on why the wound-chamber design is methodologically valuable, because it is what elevates the strongest reports above a simple observation

Elevated lactate concentrations have been demonstrated to increase the NADH/NAD+ ratio, leading to the inhibition of key glycolytic enzymes such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoglycerate dehydrogenase, ultimately suppressing both glycolysis and mitochondrial respiration (85)