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We hypothesize that the failure of intrinsic-solubility approaches arises from inaccuracies in the predicted valuesalthough Starling is a state-of-the-art p K a -prediction model, it still routinely predicts values that are wrong by 0.51.0 p K a unit, which can correspond to a 10x difference in the predicted value

doi:10.5435/JAAOS-D-22-00554

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Overview of amino acid metabolism Amino acids are organic compounds containing amino and carboxyl groups, which can be divided into -, -, -, - amino acids according to the position of the functional groups of the core structure, the most important of which are the 22 alpha-amino acids that make up proteins and 20 of these amino acids are involved in protein synthesis