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Furthermore, in another meta-analysis (Zanton et al., 2014) utilizing a compilation of 64 articles investigating the utilization of postruminally administered DL-methionine, HMTBa (offered in either a liquid form or as a calcium salt), Mepron, and Smartamine, it was observed that cows receiving Smartamine exhibited higher feed intake, whereas those supplemented with Mepron showed reduced DMI compared to the control group

Thirdly, they are manufactured using recombinant methods, resulting in high patient costs