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10.1016/j.jconrel.2021.12.032 75 HanZ.SarkarS.SmithA

Although CQDs have demonstrated substantial promise in imaging, sensing and drug delivery, advancement beyond preclinical research remains restricted by the scarcity of comprehensive toxicological data and large-scale validation, and addressing these challenges will require close interdisciplinary collaboration across chemistry, materials science, bioengineering, pharmacology, and clinical medicine to establish reliable synthesis methods, robust testing, and safety frameworks aligned with regulatory guidelines [103, 174]

The good news: visceral fat reduction and IGF-1 effects were similar in people who developed antibodies and those who did not