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Monoclonal antibodies (e.g., Lpathomab) sequester LPA and has demonstrated neuroprotective effects in central nervous system (CNS) injury models by neutralizing extracellular LPA (18:1) (93), but it also shows significant cross-reactivity with more abundant lipids such as LPC and PA (94)

The presence of congenital or acquired malabsorption syndromes, such as coeliac disease or tropical sprue, will affect absorption, and gastric stasis, whether as a result of trauma or drugs, slows the transit time through the gut

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Chronic inflammation increases white blood cells and platelets, damaging cells and microbiota, reducing organ function, and raising the risk of health issues