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Moreover, there is a potential reduction in the expression of enzymes responsible for the urea cycle, a possible re-establishment of nitrogen equilibrium, and a hypothetical modification or enhancement of nitrogen levels in different tissues

Vitamin B12 is considered beneficial and generally safe, even at high doses

Wiehle RD, Fontenot GK, Wike J, Hsu K, Nydell J, Lipshultz L, et al

To address copper-dependent toxicity in WD in human liver cells, we reanalysed the RNA sequencing data (GSE107323) [2], validated gene expression signatures and functionally addressed our findings in the HepG2 ATP7B knockout (ATP7B-KO) model [7]