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In skin SCC, the glutathione metabolism pathway is specifically enriched in the TGF--activating cancer stem cell population and is responsible for the chemoresistant property of these cells, 10 thus suggesting that glutathione metabolism might be critical for ESCC tumor progression

We found that intracellular glutathione levels in T cells cocultured with Slc7a11 -knockdown (KD) dendritic cells significantly decreased under both normal conditions and oxidative stress induced by tert-butyl hydroperoxide (TBHP) (Supplemental Figure 10, CE)

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