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What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis

FOXO4-DRI is reported to be sensitive to oxidation and repeated freeze-thaw cycles, so reconstituted material is best used fresh rather than stored for months

Retinal detachment and injury recovery Mechanism: Physical separation of retina from underlying RPE and choroid, cutting off blood supply and causing photoreceptor death within hours to days

However, more dilute concentrations may require less bacteriostatic water