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461,462,463,464 Notably, recent studies further support the pivotal role of NRF2 in intracellular metabolic reprogramming during hepatocyte proliferation, demonstrating its involvement in promoting glycolysis, nucleic acid synthesis, the oxidative pentose phosphate pathway (PPP), and NAD + /NADH synthesis, while downregulating OXPHOS

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In this review, we have highlighted studies that demonstrate how NADPH metabolism is altered in activated myeloid cells, and how the competition for NADPH consumption between oxidative and antioxidative pathways reflects a potential way to efficiently regulate the magnitude of inflammation