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These factors contribute to mitochondrial dysfunction and cognitive impairment in affected individuals ( 5.3 Manifestations of neuropsychiatric system injury Ketamine abuse commonly manifests as dissociative symptoms, such as altered consciousness, detachment from the environment, and sensory loss (Vlisides et al., 2018)

Toxicological mechanisms that are considered to be among the most significant include the generation of reactive oxygen species (ROS), oxidative stress, inflammation, genotoxicity, and cytotoxicity (197199)

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