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Adv Healthc Mater 10(6):2001676 Parthsarathy V, McClean PL, Hlscher C, Taylor M, Tinker C, Jones G, Kolosov O, Salvati E, Gregori M, Masserini M, Allsop D (2013) A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1E9 mouse model of Alzheimers disease

Acyl-CoA synthase long-chain family member 4 (ACLS4) is a fatty acid activating an enzyme that catalyzes the esterification of long-chain PUFAs such as arachidonic (AA) and adre-noyl (AdA) to form PE, which is an integral component in the GPX4-dependent ferroptosis pathway [33, 34]