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Acute soft-tissue complaints tend to shift fastest (days to a week), gut-related use is often discussed in the 2 to 4 week range, tendon and ligament work is usually a 4 to 8 week arc, and nerve-related recovery is the slowest at roughly 8 to 16 weeks

People with cancer (active or suspected): As mentioned previously, TB4 and TB-500 can promote the growth of new blood vessels, which could support the growth or spread of cancer.36 Professional athletes: TB4 and TB-500 are banned by the World Anti-Doping Agency (WADA)

Because PAN does not involve small vessels, a leukocytoclastic vasculitis rash does not occur

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