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Quick Answer: While glutathione is essential, taking too much can cause gastrointestinal distress, allergic reactions, and long-term zinc depletion

Typically, increased NADPH, which reduces glutathione, is able to compensate for elevated levels of oxidative stress caused by such triggers

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Orellana M, Rodrigo R, Varela N, Araya J, Poniachik J, Csendes A, Smok G, Videla LA (2006) Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients