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however, under specific circumstances, persistently activated mitophagy can temporarily decrease mitochondrial-derived ROS levels while releasing excessive levels of iron, which accelerates the Fenton reaction and impairs the normal function of related proteins, forming a vicious cycle that ultimately leads to irreversible iron-dependent cell death

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These pathways are complementary, not interchangeable

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487,488,489 However, these findings appear to contradict Fangs results

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