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Although there have been a limited number of studies, we found that when normalized for neuronal volume using the MRS biomarker N-acetyl aspartate, there is clear evidence for an elevation of glutamate in the early progression of ALS which is consistent with the predictions of the model of increased activity of glutamatergic neurons leading to excitotoxicity

This review explored the pathogenesis of diabetic ulcer wound healing, reveals that oxidative stress and lipid peroxidation are common pathological mechanisms of ferroptosis and delayed wound healing in diabetic ulcers

b , RT-qPCR analysis of PAPOLA mRNA expression level in the PAPOLA -knockdown HL-60 cells and U-937 cells ( n = 3 technical replicates per group)