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NRH is a new NAD + precursor that is stable in mouse plasma and is not degraded into NAM, unlike NR 125

During the subacute phase of the pathology, lactate can be utilized as an alternative energy source by some surviving neurons and astrocytes, while concurrently promoting angiogenesis and tissue repair through receptor-mediated signaling (129)

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Apart from endothelial cells, other components, such as pericytes, astrocytes, microglia, NG2-glia, oligodendrocytes, basement membrane, and perivascular macrophages, form and contribute to the proper functioning and integrity of the BBB