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461,462,463,464 Notably, recent studies further support the pivotal role of NRF2 in intracellular metabolic reprogramming during hepatocyte proliferation, demonstrating its involvement in promoting glycolysis, nucleic acid synthesis, the oxidative pentose phosphate pathway (PPP), and NAD + /NADH synthesis, while downregulating OXPHOS

Biologic therapies are better suited for advanced degeneration, chronic pain from structural issues, long-term joint deterioration, and significant tendon or ligament injury

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