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Simultaneously, it has been observed to modulate the expression of genes for proteoglycans and glycosaminoglycans (GAGs) like decorin, which are crucial for organizing collagen fibrils and maintaining tissue hydration in engineered skin equivalents

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Aging also expands the amounts of immunosuppressive M2 macrophages in many mouse tissues, e.g., bone marrow, spleen, lungs, and skeletal muscles [135, 136]