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Its working mechanism is allosteric facilitation of HGF/c-Met signaling: Dihexa binds HGF with high affinity (reported K d ~65 pM in the original work) and is proposed to potentiate HGF dimerization and c-Met phosphorylation at subthreshold endogenous HGF concentrations

Med Hypotheses 143:110185 Davis CD, Tsuji PA, Milner JA (2012) Selenoproteins and cancer prevention

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The mixture was allowed to stir for 15 min before being added dropwise to a solution of 2-ethynyl benzothiazole (200 mg, 1.2 mmol) in methanol (5 mL)