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Although, NF-B-mediated gene transcription is required for normal cellular activities, most of the cancers are associated with aberrant NF-B signaling that lead to the release of different inflammatory cytokines followed by activation of diverse arrays of tumorigenic signaling pathways (Karin, 2006, 2009)

The DCr+O group received monohydrated creatine (5 g/kg) by oral administration for the first 5 d, followed by maintenance with the 2 % creatine diet until the end of the 4-week period (adapted from Hultman et al

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