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The septic shock 3.0 definition and trials: a vasopressin and septic shock trial experience

The nasal mucosa is not designed to absorb larger peptide molecules, and most of what youre putting in your nose either degrades before reaching systemic circulation or simply doesnt cross into CNS tissue in meaningful amounts

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Common Causes of Peptide Degradation Many different processes and factors can affect peptides: Peptide hydrolysis caused by moisture exposure Oxidation resulting from oxygen and exposure to light Changes in temperature Bacterial degradation in peptide solutions Contamination during laboratory handling Repeated freeze-thaw cycles (Sigma-Aldrich, 2023a