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Signal 15 (753), eabk1147

Genes to Cells 20, 636646

Origin: Isolated from cerebral venous blood of rabbits during slow-wave sleep (1974) Mechanism of Action Delta-wave sleep promotion Cortisol modulation LH release modulation Somatostatin interaction Endorphin system modulation Primary Research Areas Sleep architecture Insomnia Stress-related sleep disturbance Circadian regulation Pain modulation Key Published Findings Promoted delta-wave sleep in EEG studies without next-day sedation Normalized disturbed sleep patterns in chronic insomnia models Reduced ACTH and cortisol levels during stress in animal models Research Protocol Commonly studied routes: Subcutaneous, Intranasal