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Studies show that while GHRP-2 and GHRP-6 administration resulted in increased plasma levels of ACTH and cortisol, ipamorelin did not release ACTH or cortisol at levels significantly different from those observed following growth hormone-releasing hormone (GHRH) stimulation

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The GlyT1 downregulation in the thalamus would result in increased glycine levels, potentially enhancing glutamatergic transmission at NMDA receptors (Frouni et al

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