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The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects

Drugs with molecular weights of 600 or greater are unlikely to penetrate milk in high concentrations.Typical examples of drugs with high molecular weights that are basically excluded from milk would include heparin (30,000), antibodies such as Remicade (144190), and insulin (6000)

This is particularly important for high milk and dairy products consuming countries such as the Netherlands, Sweden, and Spain 1,34,50,98,107,115,117,146,147,148,149

An outward-facing aromatic amino acid is crucial for signaling between the membrane-spanning and nucleotide-binding domains of multidrug resistance protein 1 (MRP1