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Declining IgG levels suggest successful immunosuppression, while persistently high levels may indicate sub-optimal therapy or ongoing inflammation, necessitating treatment adjustments [50]

*Correspondence: Bengt Mannervik, [email protected] This article was submitted to Cellular Biochemistry, a section of the journal Frontiers in Molecular Biosciences Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers