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This sequence spans the region exhibiting a significant perturbation or notable increase in the hetNOE value

112 For example, the AMP named Cecropin-XJ isolated from Xinjiang silkworm was found to have the ability to combine with the groove of tumor cell DNA and then insert into the DNA sequence, resulting in the disordered arrangement of base pairs and looseness of DNA double helix structure, leading to DNA damage and cell death

These are best treated as auxiliary hypotheses rather than primary mechanism, as the experimental support is narrower than for the VEGFR2-eNOS axis

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