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Acknowledgements: This work was supported in part by NIA grant R01 AG057381 (Ladiges, PI)

2) DSIP was shown to promote stress protective and antioxidant actions as well as enhance the efficiency of oxidative phosphorylation

You have higher levels of the chemicals homocysteine and methylmalonic acid and reduced DNA synthesis, leading to neurological and psychological symptoms, such as confusion, mood swings, problems walking or talking, and irritability

By molecular simulation, we have previously shown that YMU1 acts on the catalytic pocket of TMPK, which causes the expulsion of the lid domain to give an open conformation that inhibits the catalytic process 19