doi: 10.3390/ijms25147676 181
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When glutathione levels fall: Liver cells become more vulnerable to injury Oxidative stress increases Detoxification of toxins and hormones becomes impaired The margin between a therapeutic dose and a toxic dose of acetaminophen is narrow
In a recent investigation undertaken by our group, adult mice with partial IGF-1 showed a decrease in the expression of genes involved in glucose metabolism (phosphoenolpyruvate carboxylase-1, glucose-6-phosphatase, pyruvate dehydrogenase kinase isoenzyme-4, and ATP-citrate lyase), resulting serious hyperglycaemia [164]