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Ice packs for 1520 minutes, several times a day, can reduce inflammation and swelling

10.1097/JOM.0000000000000627 4

DNA methylation is one of the key epigenetic mechanisms for regulation of gene expression which is currently a subject of intensive research and it was reported that maternal deficiency of folate and B 12 could result in aberrant gene expression with consequential health outcomes (Reference Irwin, Pentieva and Cassidy126,Reference Monasso, Hoang and Mancano127)