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Cisplatin Nephrotoxicity Cisplatin, one of the most effective chemotherapeutic drugs, can induce damage in the renal vasculature, which leads to reduced blood flow and ischemic injury in the kidney, thereby inducing an AKI model (259)

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This functional polarization of MDSCs has been linked to factors such as endoplasmic reticulum (ER) stress, acidosis, and hypoxia, which significantly upregulate CHOP expression in intratumoral M-MDSCs and bone marrow-residing PMN-MDSCs [13]