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Indeed, we may be witnessing a protective effect on the liver associated with a further exposure of the tumour cells to ROS-induced necrosis/apoptosis

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3.3 Cancer drug screening While conventional cell-based assays remain the mainstay for initial anti-tumor drug evaluation, their predictive validity is constrained by the absence of physiological context (e.g., vascular networks, immune components), resulting in high attrition rates during clinical translation