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BACKGROUND: Incretin-based therapies such as glucagon-like peptide-1 receptor agonists (GLP-1Ras), dual GLP-1/GIP agonists and amylin analogues have demonstrated significant weight loss benefits

Health Risks and Side EffectsMisuse of boldenone is associated with a wide range of severe health disorders: Cardiovascular Issues: Risk of heart problems.Liver and Kidney Damage: Potential for hepatic (liver) and renal (kidney) impairment.Reproductive Issues: In males, it can cause decreased natural testosterone production, reduced testes size, lower sperm count, and decreased sperm mobility.Psychological Effects: Can lead to behavioral and neurochemical alterations, including anxiety, aggression, and mood disorders.Carcinogen Classification: It is classified as a probable human carcinogen by the International Agency for Research on Cancer

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To our knowledge, dogs with naturally occurring IVD degeneration have not been used, even though it is recognized that CD dog breeds are a suitable animal model of spontaneous IVD degeneration [9, 13]