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Its activity within the hypothalamicpituitary axis makes it relevant for understanding how sleep and hormones are interconnected

It may influence sleep-related signaling, circadian rhythms, and stress pathways in experimental models, though findings are limited to preclinical and in vitro studies

The results of these studies directly support the concept that proinflammatory cytokines play a major etiologic role in the development of specific organ involvement in sarcoidosis and that antiproinflammatory cytokine therapy may constitute an effective treatment