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[21] [22] [23] [24] [25] Anemia may present with a number of further common symptoms, [21] [26] including hair thinning and loss, early greying of the hair, mouth ulcers, bleeding gums, [22] angular cheilitis, a look of exhaustion with pale and dehydrated or cracked lips and dark circles around the eyes, as well as brittle nails

SIRT1 can bind and retain GAPDH in the cytosol, but SIRT5 actives GAPDH via demalonylation, thereby elevating glycolytic flux

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