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Experimental models demonstrate that FOXO proteins mediate the inhibitory effects of insulin/IGF on target genes and are essential for maintaining metabolic homeostasis

Genome-wide association studies (GWAS) further revealed that genes related to Th17 cell (such as STAT3, IL-12B) are closely associated with CD susceptibility (187)

The findings indicated that AST/Bex treatment restrained transcription and activity of the amyloidogenic enzyme BACE1, consequently decreasing A oligomers as well as 80-kDa intracellular APP/A species