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Bacterial challenges generally induced multiple GSTs, however individual members of the GST family were specifically modified depending upon the virulence of bacterial strains and the outcome of interaction

These changes included mucosal erosion, ulcerative lesions, deformation and distortion of colonic recesses, extensive infiltration of inflammatory cells (primarily lymphocytes and neutrophils) in the mucosa and submucosa, and depletion of goblet cells

These proteins are integral to chromatin structure and gene regulation, and their interaction with small peptides may influence epigenetic mechanisms

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