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A substantial body of research has confirmed the positive effect of polyamines on human health, including potential benefits in cancer [256], age-related diseases [70], and neurodegenerative diseases [188]

Interaction Effects of the 5-HTT and MAOA-UVNTR Gene Variants on Pre-Attentive EEG Activity in Response to Threatening Voices. Communications Biology, vol

Proposed pathways include modulation of multiple neurotransmitter systems (influencing serotonin, dopamine, norepinephrine, GABA, glutamate levels), possible involvement of NMDA receptors, alpha-1 adrenergic signaling (e.g., potentiating pineal acetyltransferase activity), inhibition of somatostatin release via dopaminergic routes, reduced ACTH/cortisol for stress buffering, and stimulated growth hormone or somatoliberin secretion

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