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The final part of this group is the thioredoxin (Trx) system, another thiol-based redox mechanism that is independent of GSH

545 For example, pelacarsen, an Lp(a) ASO drug developed by Ionis in collaboration with Novartis AG, effectively lowers Lp(a) levels by selectively cleaving Apo(a) gene (LPA) mRNA

Although it might be cruel to imagine that poor cysteine has no feet, it will help us understand how glutathione keeps him from getting into trouble if we imagine the sulfhydryl group as his head and the carboxyl and amino groups as his hands

This NBC-Los Angeles news story that aired Wednesday also does a good job summarizing concerns