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This inhibition reduces intracellular 1-methylnicotinamide (1-MNA) production (EC50 = 2.3 M) and preserves nicotinamide availability for the NAD+ salvage pathway

Furthermore, the analysis highlighted strong reductions in the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), confirming berberine's role as a potent insulin sensitizer

Extracts of ligustrum can improve the elevation of lactate dehydrogenase and creatinine in the serum of rats caused by oxidative stress (44)

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