The compound demonstrates exceptional target selectivity, with no inhibition of related methyltransferases (DNMT1, PRMT3, COMT) or NAD+ salvage enzymes (NAMPT, SIRT1) at concentrations up to 600 M
a separate Merck Phase 2b trial in hip-fracture patients (Adunsky et al., 2011, PMID 21067829) was stopped early after a cardiac safety signal emerged
The net effect is a middle ground: you get some of the targeted visceral fat reduction that tesamorelin delivers, combined with the broader recovery, sleep, and muscle benefits that ipamorelin provides
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