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Hydroxyl radicals are extremely reactive and may cause extensive damage to cellular components

Homocysteine and risk of premature coronary heart disease

To assess whether this interaction is physiologically relevant, we immunoprecipitated ASXL1 from soluble nuclear extracts of K562 cells expressing Flag-Strep-tagged ASXL1 and identified potential ASXL1-binding partners by mass spectrometry (MS)