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Simultaneously, mechanical cues activates the Hippo pathway effector Yes-associated protein 1 (YAP), which translocates to the nucleus, where it promotes the transcription of profibrotic genes, reinforcing ECM deposition and stiffness (129)

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The name "KLOW" is a brand designation rather than a pharmacological classification the formulation is also referenced in the research community as the "Wolverine stack" or "Wolverine peptide blend," though those informal nicknames appear nowhere in the published literature

Their ALS progressed slower and they survived for much longer than untreated patients