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When intracellular GSH levels were depleted activation of caspase 3 was less, being 30 and 40% for AQ-QI and DEAQ-QI, respectively

demonstrated thaterastin and RSL3 induced renal tubular cell death accompanied by high ACSL4 levels in vitro , while the ACSL4 inhibitor rosiglitazone improved the survival rate and alleviated kidney injury in diabetic nephropathy mice, and decreased lipid peroxidation products and iron content (Wang et al., 2020)