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By mitigating lipid peroxidation, protein oxidation, and DNA damage, antioxidants help preserve BBB permeability and prevent the infiltration of neurotoxic blood-derived substances into the brain [150,206]

Mitochondrial-mediated ROS cause oxidative damage to cellular structures, particularly mitochondrial DNA, somatic mutations, genome instability, inactivation of tumor suppressor genes, alterations in metabolic and signaling pathways with simultaneous activation of compensatory antioxidant mechanisms, all of which contribute to cell transformation and thus promote various types of cancer [42]

A supervised program will say no when the clinical picture requires it

Stem Cells 33 , 23812390 (2015)