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Platelet-rich plasma and mesenchymal stem cell therapies have the strongest evidence to date, showing moderate improvements in pain and function with generally favorable safety profiles, though long-term structural regeneration remains unproven

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However, the addition of trisomy 21 in the first case, and raised adenosine in the second, brings the profiles much closer to those observed in patients with Down syndrome and autism, respectively

Additionally, glutathione levels naturally decrease with age, partly due to a decline in the rate of synthesis