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In Social Isolation and Loneliness in Older Adults: Opportunities for the Health Care System (National Academies Press (US) Copyright 2020 by the National Academy of Sciences

Increased infiltration of local neutrophil extracellular traps (NETs) around intestinal microvasculature, accompanied by increased ferroptosis of endothelial cells, was detected in both intestinal I/R patients and animal models, which may be a major cause of microcirculation dysfunction

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At the molecular level, glycine works through several complementary pathways