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This therapy utilizes a small molecule known as 5-Amino-1MQ, which targets an enzyme called Nicotinamide N-methyltransferase (NNMT)
Consistent with the distribution of Firmicutes in the cecal samples, the relative abundance of Ileibacterium was highest in the WD controls (average relative abundance 68%), second highest in the LD controls (average relative abundance 51%), and lowest in the vehicle- and 5A-1MQ-treated mice switched from WD to LD (average relative abundances of 40% and 41%, respectively)
5Amino-1MQ 5-Amino-1MQ is a small-molecule compound targeting the NNMT pathway, and its currently being studied for its role in cellular metabolism, energy regulation, and adipocyte-related biochemical models
Hydroxocobalamin Another man-made injectable form of vitamin B12 is hydroxocobalamin, which lasts longer in the bloodstream and requires fewer injections than cyanocobalamin
